Thionyl Chloride → HCID 178456134, compound

Participants

Reaction Conditions

Reaction Steps

trans-4-cyanocyclohexanecarboxylic acid (7.7 g; 0.05 mol) and thionyl chloride (8.0 g; 0.066 mol) was mixed and refluxed for 30 min. Excess thionyl chloride was evaporated in vacuum. Paraldehyde (2.5 g; 0.062 mol) and a catalytic amount of zinc chloride were added and the mixture was heated at 90° C. for 11/2 h with stirring. The cooled mixture was extracted with ether, washed with sodium bicarbonate solution, dried and evaporated, the product was distilled at 112° C./1 Pa. Yield 6.5 g of an oil.

Provenance & Evidence