Chloroform → HCID 178472365, compound

HRID 1979963Notes

Reaction equation

HRID 1979963 reaction equation
[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([O:11][CH:12]([O:14][C:15]([C@H:17]2[CH2:22][CH2:21][C@H:20]([C:23]#[N:24])[CH2:19][CH2:18]2)=[O:16])[CH3:13])=[O:10])[CH2:5][CH2:4]1)#[N:2].C(Cl)(Cl)[Cl:26]>C(O)C.[Pt]=O>[ClH:26].[ClH:26].[NH2:2][CH2:1][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([O:11][CH:12]([O:14][C:15]([C@H:17]2[CH2:18][CH2:19][C@H:20]([CH2:23][NH2:24])[CH2:21][CH2:22]2)=[O:16])[CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

5

Reactant 2

HCID 6212ChloroformHCID 178472364HCID 178472364, compound

Product 1

HCID 178472365HCID 178472365, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

1,1-Ethandiol bis-(trans-4-cyanocyclohexanecarboxylate) (6 g) was dissolved in a mixture of anhydrous ethanol and chloroform. Platinum oxide (1 g) was added and the mixture was hydrogenated at 3.1 MPa at 22° C. for 15 h. The catalyst was filtered off and the solvent evaporated. The product was crystallized from a mixture of 2-propanol and methanol. Yield 5.5 g, m.p. 260° C.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. customThe product was crystallized from a mixture of 2-propanol and methanol

Sources & evidence

ORD record
ord-c2077ed673ca448294122347a61b3ca8
Source dataset
uspto-grants-1984_11
Patent number
US04483867

Reaction notes

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