HCID 178456134, compound → HCID 178472364, compound

Participants

Reaction Steps

Trans-4-cyanocyclohexanecarboxylic acid (11.5 g; 0.075 mol) and tetrabutylammonium hydrogen sulfate (25.5 g; 0.075 mol) was dissolved in 2M sodium hydroxide and extracted with ethanolfree chloroform. The chloroform solution was dried and the solvent evaporated. The residue was dissolved in trichloroethylene (600 ml) and 1-(trans-4-cyanocyclohexanoyloxy)ethyl chloride (10.8 g; 0.05 mol) was added. The solution was refluxed for 8 h. It was then washed, dried and evaporated. Yield 17.1 g, m.p. 75°-76° C.

Provenance & Evidence