HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroacetate → methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | 2-methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | HCID 27290 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | HCID 54676532 | — |
Reaction Steps
In a manner similar to Examples 15 and 16, to a solution of 2.86 g. (50 mmoles) of N-methylsaccharin and 10.8 ml. (100 mmoles) of methyl chloroacetate in 17 ml. of dimethylsulfoxide was added 11.56 g. (170 mmoles) of sodium ethoxide in 63 ml. of dimethylsulfoxide over a period of 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04483982 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-f6fd8fba62024f60949a4e58cac83bbe |
| Source note | uspto-grants-1984_11 |