HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroacetate → methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | 2-methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | HCID 27290 | — |
| Reactant | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt | HCID 45051783 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | HCID 54676532 | — |
Reaction Steps
To 870 mg. (4.4 mmoles) of N-methylsaccharin and 0.95 ml. (10.89 mmoles) of methyl chloroacetate in 3 ml. of dimethylsulfoxide under nitrogen was added at the rate of 0.084 ml./minute 3.99 g. (20 mmoles) of potassium hexamethyl disilazane in 9.98 ml. of dimethylsulfoxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04483982 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-5debe166629a4fe69efd29c56af595dc |
| Source note | uspto-grants-1984_11 |