Sodium Carbonate → HCID 13363169, compound

Participants

Reaction Conditions

Reaction Steps

To an aqueous solution of trans-2,5-pyrrolidine dicarboxylic acid monoethyl ester (4.8 g, 0.25 m) at 5° C. was simultaneously added benzyl chloroformate (4.8 ml, 0.032 m) and a solution of sodium carbonate (5.4 g, 0.05 m) in water (20 ml). The mixture was stirred at 5° C. for 45 minutes and then extracted with ether. The aqueous mixture was acidified to pH 3 with dilute hydrochloric acid and extracted with diethyl ether. The combined extracts were washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated to yield the title compound as an oil.

Provenance & Evidence