Mercapto-ethanol → HCID 13363162, compound

Participants

Reaction Steps

To a solution of 1.08 g (9.7 mmole) of potassium t-butoxide in 30 ml of cold (circa 0°) t-butyl alcohol was added 0.8 g (12.9 mmole) of mercaptoethanol, and the mixture was allowed to warm to room temperature. The title compound of Example 19 (2.05 g, 6.4 mmole) was added and the mixture was heated at reflux for two hours. Upon cooling, the mixture was concentrated in vacuo and the residue was treated with 50 ml of water. The mixture was extracted with chloroform/dichloromethane and the organic phase was washed with water, dried over magnesium sulfate, filtered, and concentrated to dryness. Column chromatography of the crude product on silica gel afforded 350 mg of the title compound, m.p. 120°-122°.

Provenance & Evidence