HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → (S)-alpha-(Trifluoromethyl)benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | HCID 12735480 | HCID 12735480 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-alpha-(Trifluoromethyl)benzyl alcohol | HCID 95556 | — |
Reaction Steps
In Example 20, by using tin chloride instead of zinc powder, trifluoromethyl was caused to react with trifluoromethyl iodide (SnCl2), as in the case of the Example 20, and CF3SnCl2I was obtained. Consecutively, as in the case of the Example 20, CF3SnCl2I was put into a flask together with benzaldehyde and dimethylformamide, and subjected to reaction under the action of ultrasonic waves, and the product extracted from an oil layer generated was hydrolyzed, thereby phenyltrifluoromethylcarbinol was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04484993 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-1fb53be9fc704f709326811aedda1972 |
| Source note | uspto-grants-1984_11 |