Acetic Acid → 6-Chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine

HRID 1980086Notes

Reaction equation

HRID 1980086 reaction equation
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([NH:12][NH2:13])=[N:4][N:3]=1.C(O)(=O)C.[N:18]([O-])=O.[Na+]>O>[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[N:18][N:4]2[N:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 640098866597-78-2HCID 23668193Sodium Nitrite

Product 1

HCID 133767996-Chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 9.9 g of 1-chloro-4-hydrazino-5,6,7,8-tetrahydrophthalazine in 35 ml of aqueous 12% acetic acid was added a solution of 3.5 g of sodium nitrite in 30 ml of water. The mixture was kept at room temperature (about 22°-25° C.) for about 20 minutes. The solid present was then separated by filtration, air dried and recrystallized to give 6-chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine melting at about 109°-110° C.

Workup

  1. customwas kept at room temperature
  2. custom(about 22°-25° C.)
  3. customfor about 20 minutes
  4. customThe solid present was then separated by filtration, air
  5. customdried
  6. customrecrystallized

Sources & evidence

ORD record
ord-9fef7071c1824178b56019af0b9fc8a0
Source dataset
uspto-grants-1984_11
Patent number
US04485106

Reaction notes

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