2-Pyrrolidone → HCID 13376802, compound

HRID 1980089Notes

Reaction equation

HRID 1980089 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[N:14][N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][C:16]1=O>CO>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][N:13]=[N:14][N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 120252-PyrrolidoneHCID 133767996-Chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine

Product 1

HCID 13376802HCID 13376802, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6 g of 6-chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine, 150 ml of methanol and excess pyrrolidone was heated on a boiling-water steam bath for 10 minutes and cooled. The solid which formed was separated by filtration, washed with water and recrystallized from a mixture of dimethylsulfoxide and water to give 6-(1-pyrrolidinyl)-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine melting at about 272°-273° C.

Workup

  1. temperaturewas heated on a boiling-water steam bath for 10 minutes
  2. temperaturecooled
  3. customThe solid which formed
  4. customwas separated by filtration
  5. washwashed with water
  6. customrecrystallized from a mixture of dimethylsulfoxide and water

Sources & evidence

ORD record
ord-e1e82971bdd949d192880c9579687d46
Source dataset
uspto-grants-1984_11
Patent number
US04485106

Reaction notes

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