Methyl iodide → HCID 20437408, compound

HRID 1980090Notes

Reaction equation

HRID 1980090 reaction equation
[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH3:24][I:25]>CO>[I-:25].[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N+:4]1([CH3:24])[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20437405HCID 20437405, compound

Product 1

HCID 20437408HCID 20437408, compoundYield 545.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-[2-hydroxy-3-(1-naphthalenesulphonamido)propyl]pyrrolidine (2 g; 0.0005 mol) in methanol (50 ml) was added methyl iodide (6.9 g; 0.05 mol). The mixture was left at room temperature 12 hours. The reaction mixture was evaporated to dryness and the residue was recrystallized from ethanol (20 ml) to obtain the product (1.3 g).

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customthe residue was recrystallized from ethanol (20 ml)

Sources & evidence

ORD record
ord-dfe7be1f650f49aaa7511649034dfcf6
Source dataset
uspto-grants-1984_11
Patent number
US04485108

Reaction notes

Loading…