Chloroform → 1,1'-{5-[3-(tert-Butylamino)-2-hydroxypropoxy]-1-benzofuran-2,4-diyl}di(ethan-1-one)--hydrogen chloride (1/1)

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Reaction Steps

8.9 g of (±)-2,4-diacetyl-5-(3-tert-butylamino-2-hydroxy-propyloxy)-benzofuran in solution in CHCl3 are charged in a reactor cooled externally with an ice bath, then a stream of gaseous HCl is bubbled up to saturation. After evaporation of CHCl3 under reduced pressure, a precipitate is obtained which is taken up in CHCl3, triturated drained and dried. 9.2 g of the expected product are obtained, m.p.=214°-216° C.

Provenance & Evidence