Methyl Ethyl Ketone → HCID 13363417, compound

Participants

Reaction Steps

4-(3'-Methoxyphenyl)-α,1-dimethyl-α-ethyl-4-piperidinemethanol was prepared from 3-bromoanisole by the procedure described in Example 2 except that methyl ethyl ketone (2-butanone) was used in place of acetone in the preparation of III; m.p. 134°-135°; NMR (in CDCl3): τ2.6-3.3 (m, 4H); 6.2 (s, 3H); 7.2-8.3 (m, 12H); 8.6 (quartet, 2H); 9.0 (s, 3H) and 9.2 (t, 3H). Anal. Calcd. for C17H27NO2 : C, 73.61; H, 9.81; N, 5.05. Found: C, 73.73; H, 9.69; N, 5.17.

Provenance & Evidence