HCID 178440758, compound → HCID 178445603, compound

Participants

Reaction Steps

An approximately 1:1 cis/trans mixture of 2-(4'-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquine (see Example 1) (10 g) was dissolved in concentrated sulphuric acid (100 ml) and the solution maintained at various temperatures for various periods of times as shown below. At the end of the reaction the reaction mixture was cooled and poured dropwise into ice/water to provide crude product which was purified by recrystallisation as previously described and/or column chromatography. The isomers ratios of the product were determined by NMR, GLC.; the results shown below.

Provenance & Evidence