HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine → 4-(Bis(4-fluorophenyl)methylene)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine | HCID 13519965 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Bis(4-fluorophenyl)methylene)piperidine | HCID 2724436 | — |
Reaction Steps
A mixture of 1.6 parts of 4-[bis(4-fluorophenyl)-methylene]-1-(phenylmethyl)piperidine and 80 parts of methanol was hydrogenated at normal pressure and at room temperature with 1 part of rhodium-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 1.2 parts of 4-[bis(4-fluorophenyl)methylene]piperidine as a residue (intermediate 14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04485107 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-0822a6f117754669a6ef2bf9eab6dd1a |
| Source note | uspto-grants-1984_11 |