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Pyridine → N-[4-(hexadecylamino)benzoyl]-2-methylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Aminoisobutyric acid | HCID 6119 | — |
| 反応物 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-2-methylalanine | HCID 20437359 | — |
反応手順
A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04485105 |
| 出典データセット | uspto-grants-1984_11 |
| ORD ID | ord-b1efaf5be7ff49edab73a62b7edbcb0b |
| 出典メモ | uspto-grants-1984_11 |