Pyridine → HCID 88706309, compound

HRID 1980233Notes

Reaction equation

HRID 1980233 reaction equation
[OH:1][CH2:2][C:3]([S:5][C@H:6]1[N:9]([C:10]([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][CH:35]=2)=[O:31])=[P:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8](=[O:43])[C@@H:7]1[C@H:44]([O:46][C:47]([O:49][CH2:50][C:51]1[CH:56]=[CH:55][C:54]([N+:57]([O-:59])=[O:58])=[CH:53][CH:52]=1)=[O:48])[CH3:45])=[O:4].N1C=CC=CC=1.[C:66](OC(=O)C)(=[O:68])[CH3:67]>C(Cl)Cl>[C:66]([O:1][CH2:2][C:3]([S:5][C@H:6]1[N:9]([C:10]([C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][CH:35]=2)=[O:31])=[P:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:8](=[O:43])[C@@H:7]1[C@H:44]([O:46][C:47]([O:49][CH2:50][C:51]1[CH:52]=[CH:53][C:54]([N+:57]([O-:59])=[O:58])=[CH:55][CH:56]=1)=[O:48])[CH3:45])=[O:4])(=[O:68])[CH3:67]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 13187795HCID 13187795, compound

Product 1

HCID 88706309HCID 88706309, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred solution of 4(R)-hydroxyacetylthio-3(S)-[1(R)-p-nitrobenzyloxycarbonyloxyethyl]-1-(1-p-nitrobenzyloxycarbonyl-1-triphenylphosphoranylidenemethyl)-azetidin-2-one (418 mg, 0.5 mmole) in CH2Cl2 (5 ml) was sequentially treated with pyridine (162 mg) and acetic anhydride (90 mg) and then stirred at room temperature for six hours.

Sources & evidence

ORD record
ord-4688fbed6c884f319db231769267d301
Source dataset
uspto-grants-1985_04
Patent number
US04508649

Reaction notes

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