HCID 23318336, compound → HCID 13175725, compound

Participants

Reaction Conditions

Reaction Steps

4 g of 7-methyl-1-(β-chloroethyl)-2-chloromethyl-5-(2-furyl)-2,3-dihydro-1H-1,4-benzodiazepine 4-oxide (prepared analogously to Example 5A-C) are dissolved in 10 ml of n-butylamine and the solution is heated to 90° C. in an autoclave for 14 hours. After the reaction mixture has been worked up, the resulting crude product is purified by chromatography on aluminium oxide of activity level II, using methylene chloride/chloroform, and is crystallised from ether. 2.1 g of 1,2,3,4,4a,5-hexahydro-3-(n-butyl)-9-methyl-7-(2-furyl)-pyrazino[1,2-a][1,4]benzodiazepine 6-oxide are obtained. Melting point: 104° to 106° C.

Provenance & Evidence