Hydrochloric Acid → HCID 13423963, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 10.4 g (0.029 mole) of 1-benzyl-3-ethoxy-3-[(2-ethoxyphenoxy)methyl]pyrrolidine in 100 ml of 200 ethanol was treated with palladium/carbon catalyst and shaken at 70° C. under a hydrogen atmosphere for 16 hours. No hydrogen was absorbed. The catalyst was removed by filtration, the filter cake washed with 50 ml of 200 ethanol, the filtrate transferred to a Parr reaction bottle and treated with 29 ml of 1.00N hydrochloric acid. Palladium/carbon catalyst was added and the reaction mixture was shaken under a hydrogen atmosphere at 70° C. for 16 hours. The catalyst was removed by filtration, and the filtrate evaporated under reduced pressure (9.0 g). The product hydrochloride crystallized on standing and was recrystallized twice from isopropanol-isopropyl ether: 5.7 g, (65%), m.p., 109°-112° C. The salt was dried under vacuum.

Provenance & Evidence