Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 13423981 | HCID 13423981 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 13423985 | HCID 13423985 | 72.5% |
Reaction Steps
A solution of 6.5 g (0.02 mole) of 4-[(2-ethoxyphenoxy)methyl]-1-phenylmethyl-4-piperidinol in 100 ml of dry acetone was stirred at 10° C. while 4.2 g (0.03 mole) of methyl iodide was added in one portion. The solution was warmed to 30° C. and allowed to cool while stirring overnight. The solid precipitate was collected by filtration to yield 7 g (72.5%) of pale yellow crystals, m.p. 187°-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04508724 |
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| Source dataset | uspto-grants-1985_04 |
|---|
| ORD ID | ord-d9394171dc044a9c8101662ff80618cf |
|---|
| Source note | uspto-grants-1985_04 |
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