Water → HCID 20402697, compound

Participants

Reaction Steps

A mixture of 5-(2-chlorophenyl)-1,7-dihydro-3-hydroxy-1,6,7-trimethyl-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one (4.75 g, 0.0149 mole), benzoyl chloride (2.45 g, 0.0174 mole) and triethylamine (4.5 g, 0.0445 mole) in benzene (100 ml) is refluxed for about 2 hours. Benzene is then boiled off under vacuum and the residue is taken up with a small amount of water and filtered. The raw material thus obtained is crystallized from ethanol yielding 4.9 g of the compound of the title. M.p. 228°-29° C.

Provenance & Evidence