Potassium Iodide → HCID 20402707, compound

HRID 1980264Notes

Reaction equation

HRID 1980264 reaction equation
[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18]Cl)=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I-:21].[K+]>C(O)C>[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18][I:21])=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4875Potassium IodideHCID 20402708HCID 20402708, compound

Product 1

HCID 20402707HCID 20402707, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(4-benzoyl-1,5-dimethyl(1H)pyrrol-3-yl)2-chloroacetamide (0.741 mole) and potassium iodide (1.62 mole) were refluxed in ethanol (3400 ml) for 5 hours with stirring. The reaction mixture was then cooled, the inorganic salts were filtered and the solvent was evaporated under vacuum. The obtained residue was purified by washing first with water and then with cold ethanol. M.p. 135°-137° C. Yield 87%.

Workup

  1. temperatureThe reaction mixture was then cooled
  2. filtrationthe inorganic salts were filtered
  3. customthe solvent was evaporated under vacuum
  4. customThe obtained residue was purified
  5. washby washing first with water

Sources & evidence

ORD record
ord-fc68db725e3742248918ab097b11d96b
Source dataset
uspto-grants-1985_04
Patent number
US04508730

Reaction notes

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