HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-(1-Phenyl-3-dimethylaminopropoxy)-isoflavone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7-Hydroxyisoflavone | HCID 5376891 | — |
| Reactant | 3-Chloro-N,N-dimethyl-3-phenylpropan-1-amine | HCID 12707239 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-(1-Phenyl-3-dimethylaminopropoxy)-isoflavone | HCID 12918914 | — |
Reaction Steps
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 23.8 g of 7-hydroxyisoflavone in 100 ml of CH2Cl2, 20 g of 1-chloro-1-phenyl-3-dimethylaminopropane is added dropwise while stirring and stirring is continued for a further hour. Working up in the customary manner gives 7-(1-phenyl-3-dimethylaminopropoxy)-isoflavone. M.p. 128°-130°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04508732 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-a563512d920e49bbbf2b6540902d8910 |
| Source note | uspto-grants-1985_04 |