HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Imidapril tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine | HCID 5702571 | — |
| Reactant | tert-Butyl (4S)-1-methyl-2-oxoimidazolidine-4-carboxylate | HCID 13053976 | — |
| Product | Imidapril tert-Butyl Ester | HCID 14801864 | 70.5% |
Reaction Steps
560 mg of (2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionic acid, 230 mg of 1-hydroxysuccinimide, 413 mg of dicyclohexylcarbodiimide and 400 mg of tert.-butyl (4S)-1-methyl-2-oxo-imidazolidine-4-carboxylate are treated in the same manner as described in Example 1-(1), whereby 650 mg of tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate are obtained as colorless viscous oil. Yield: 70.4%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04508727 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-600f4108d3644d898409dfe98c164bc6 |
| Source note | uspto-grants-1985_04 |