HCID 57115635, compound → HCID 13456353, compound

HRID 1980279Notes

Reaction equation

HRID 1980279 reaction equation
[CH3:1][N:2]1[CH2:6][C@@H:5]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])[N:4]([C:17](=[O:35])[C@@H:18]([NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:19])[C:3]1=[O:36]>[Pd]>[CH3:1][N:2]1[CH2:6][C@@H:5]([C:7]([OH:9])=[O:8])[N:4]([C:17](=[O:35])[C@@H:18]([NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:19])[C:3]1=[O:36]

Participants

3

Reactant 1

HCID 57115635HCID 57115635, compound

Product 1

HCID 13456353HCID 13456353, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1.95 g of benzyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 50 mg of palladium black are treated in the same manner as described in Example 1-(2), whereby 1.49 g of (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid are obtained as colorless crystals. Yield: 93.1%

Sources & evidence

ORD record
ord-2b815596b58f4860b2bd5d973644262c
Source dataset
uspto-grants-1985_04
Patent number
US04508727

Reaction notes

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