HCID 131714186, compound → HCID 13456371, compound

HRID 1980281Notes

Reaction equation

HRID 1980281 reaction equation
[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([O:15]CC2C=CC=CC=2)=[O:14])[N:10]([C:23](=[O:41])[C@@H:24]([NH:26][C@H:27]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH3:25])[C:9]1=[O:42])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([OH:15])=[O:14])[N:10]([C:23](=[O:41])[C@@H:24]([NH:26][C@H:27]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH3:25])[C:9]1=[O:42])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 131714186HCID 131714186, compound

Product 1

HCID 13456371HCID 13456371, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2.6 g of benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 100 mg of palladium black are treated in the same manner as described in Example 1-(2), whereby 1.97 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid 1/4 hydrate are obtained as colorless crystals. Yield: 89.1%

Sources & evidence

ORD record
ord-fae9cdaec94d43ddb88d61ad0e279744
Source dataset
uspto-grants-1985_04
Patent number
US04508727

Reaction notes

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