HCID 57176538, compound → HCID 13456344, compound

HRID 1980283Notes

Reaction equation

HRID 1980283 reaction equation
[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([O:15]CC2C=CC=CC=2)=[O:14])[N:10]([C:23](=[O:46])[C@@H:24]([NH:26][C@H:27]([C:36]([O:38]CC2C=CC=CC=2)=[O:37])[CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH3:25])[C:9]1=[O:47])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([OH:15])=[O:14])[N:10]([C:23](=[O:46])[C@@H:24]([NH:26][C@H:27]([C:36]([OH:38])=[O:37])[CH2:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH3:25])[C:9]1=[O:47])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 57176538HCID 57176538, compound

Product 1

HCID 13456344HCID 13456344, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

5.4 g of benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 300 mg of palladium black are treated in the same manner as described in Example 1-(2), whereby 3.23 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid are obtained as colorless crystals. Yield: 83.6%

Sources & evidence

ORD record
ord-18299eca1b36405eb6e9b016a284978b
Source dataset
uspto-grants-1985_04
Patent number
US04508727

Reaction notes

Loading…