HCID 56617974, compound → HCID 13456375, compound

HRID 1980284Notes

Reaction equation

HRID 1980284 reaction equation
[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([O:15]CC2C=CC=CC=2)=[O:14])[N:10]([C:23](=[O:46])[C@@H:24]([NH:26][C@H:27]([C:36]([O:38]CC2C=CC=CC=2)=[O:37])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH3:25])[C:9]1=[O:47])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH2:12][C@@H:11]([C:13]([OH:15])=[O:14])[N:10]([C:23](=[O:46])[C@@H:24]([NH:26][C@H:27]([C:36]([OH:38])=[O:37])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH3:25])[C:9]1=[O:47])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 56617974HCID 56617974, compound

Product 1

HCID 13456375HCID 13456375, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

4.3 g of benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 200 mg of palladium black are treated in the same manner as described in Example 1-(2), whereby 2.81 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-carboxy-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid are obtained as colorless crystals. Yield: 90.9%

Sources & evidence

ORD record
ord-b36db5740a23415ab7dc216ca332d89f
Source dataset
uspto-grants-1985_04
Patent number
US04508727

Reaction notes

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