1,4-Dioxane hydrochloride → HCID 56634859, compound

Participants

Reaction Steps

0.7 g of tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-isopentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 20 ml of a 13% hydrogen chloride-dioxane solution are treated in the same manner as described in Example 10-(3), whereby 0.55 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-isopentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless viscous oil. This oil (0.55 g) and 20 mg of palladium black are treated in the same manner as described in Example 10-(5), whereby 0.35 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-carboxy-isopentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless cyrstals. Yield: 68% This product begins to gradually decompose at about 141° C.

Provenance & Evidence