1,4-Dioxane hydrochloride → HCID 56635572, compound

Participants

Reaction Steps

1.2 g of tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 30 ml of a 13% hydrogen chloride-dioxane solution are treated in the same manner as described in Example 10-(3), whereby 1.0 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]-propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless viscous oil. This oil (1.0 g) and 50 mg of palladium black are treated in the same manner as described in Example 10-(5), whereby 0.75 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-carboxy-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless crystals. Yield: 84.3%

Provenance & Evidence