1,4-Dioxane hydrochloride → HCID 56618154, compound

Participants

Reaction Steps

0.6 g of tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-2-phenylethyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate and 20 ml of a 20% hydrogen chloride-dioxane solution are treated in the same manner as described in Example 10-(3), whereby 0.47 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-2-phenylethyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless viscous oil. This oil (0.47 g) and 30 mg of palladium black are treated in the same manner as described in Example 10-(5), whereby 0.32 g of (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-carboxy-2-phenylethyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid is obtained as colorless crystals. Yield: 71.1%

Provenance & Evidence