HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 2-Amino-5-(4-chlorophenyl)pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Amino-5-(4-chlorophenyl)pyridine-3-carbonitrile | HCID 13242642 | — |
| Product | 2-Amino-5-(4-chlorophenyl)pyridine-3-carboxylic acid | HCID 13242643 | — |
Reaction Steps
An alkaline hydrolysis procedure may also be used to synthesize the desired compound. Accordingly, 2-amino-5-(4-chlorophenyl)-3-pyridinecarbonitrile (2.0 grams) and KOH (2.0 grams) in 30 ml ethylene glycol were heated at 150° C. in an oil bath. After 3 hours the reaction was complete and the alkaline solution was poured into ice water and acidified to give the desired solid. The final product was again confirmed by NMR, yield 2.3 grams, m.p. 300°-315° C. dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04508722 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-d58b553aad6e4b43a1ae06c17debfb69 |
| Source note | uspto-grants-1985_04 |