2-Pyridinamine, 4-methyl-5-phenyl- → HCID 13242651, compound

HRID 1980313Notes

Reaction equation

HRID 1980313 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:14][C:15]1[C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:19][N:18]=[C:17]([NH2:27])[CH:16]=1>ClCCl>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:27][C:17]1[CH:16]=[C:15]([CH3:14])[C:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:19][N:18]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 98990242-Pyridinamine, 4-methyl-5-phenyl-HCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 13242651HCID 13242651, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,6-Dichlorobenzoyl isocyanate (1.4 grams) was reacted with 4-methyl-5-phenyl-2-pyridylamine (0.9 gram) in dichloromethane. There was an immediate exotherm and spontaneous reflux. The reaction mixture was then stirred at ambient temperature but no precipitate formed. After the mixture was stripped, the residue was recrystallized from ethanol yielding 1.0 gram of tan crystals, m.p. 210°-214° C. The identity of the desired product was confirmed by NMR.

Workup

  1. customno precipitate formed
  2. customthe residue was recrystallized from ethanol yielding 1.0 gram of tan crystals, m.p. 210°-214° C

Sources & evidence

ORD record
ord-70f453488fba487ebf8631132922de30
Source dataset
uspto-grants-1985_04
Patent number
US04508722

Reaction notes

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