Acetic Acid → 2-Amino-6-chloro-5-(4-chlorophenyl)pyridine-3-carboxylic acid

Participants

Reaction Steps

2-Amino-6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid, ethyl ester (0.3 gram) was partially dissolved in 3 ml water and 3 ml dioxane and then 0.2 gram of sodium hydroxide was added. The reaction mixture was refluxed for 11/2-2 hours and, after the mixture was neutralized with glacial acetic acid, a precipitate formed which was collected and washed with water, yield approximately 250 mg, m.p. 280°-284° C. dec.

Provenance & Evidence