反应详情

To a solution of ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-2-pentenoate (0.8 g) in ethanol (25 ml), chilled in an ice bath and under nitrogen, ammonia is flowed over for about 10 minutes while stirring. Reaction is allowed to warm to R.T. The reaction is again chilled and additional ammonia added for about 15 minutes. Reaction is allowed to rise to R.T. and stirring continued over night. Reaction is concentrated under vacuum to an oil. The oily concentrate is purified by prep. thin layer chromatography using ethyl acetate/hexane (1:1) to give ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-aminopentanoate (purity 93.7%, structure confirmed by MS).

1. customis flowed over for about 10 minutes
2. customReaction
3. temperatureThe reaction is again chilled
4. customReaction
5. customto rise to R.T.
6. stirringstirring
7. waitcontinued over night
8. customReaction
9. concentrationis concentrated under vacuum to an oil
10. concentrationThe oily concentrate
11. customis purified by prep