HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → Methyl (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamodithioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Methyl (2-hydroxyethyl)carbamodithioate | HCID 13277332 | — |
| Catalyst | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | Methyl (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamodithioate | HCID 54082931 | 101.5% |
Reaction Steps
To a solution of N-(2-hydroxyethyl)dithiocarbamic acid methyl ester (81.7 g) in dichloromethane (300 ml) are added dihydropyran (54 g) and toluene-p-sulfonic acid monohydrate (1.0 g), and the mixture is stirred for 1 hour. The reaction mixture is poured in aqueous sodium hydrogen carbonate, shaken and the resulting organic layer is separated. The layer is concentrated under reduced pressure to give N-[2-(2-tetrahydropyranyl)oxyethyl]dithiocarbamic acid methyl ester (129 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04508909 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-34dd4e80b2bb436e821b2d27aa80360f |
| Source note | uspto-grants-1985_04 |