Isopropylamine → HCID 178457116, compound

HRID 1980385Notes

Reaction equation

HRID 1980385 reaction equation
[CH3:1][N:2]1[C:6]([OH:7])=[C:5]([C:8](=[O:17])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:4]([CH3:18])=[N:3]1.C(N)(C)C>C1C=CC=CC=1>[CH:4]([NH2:3])([CH3:18])[CH3:5].[CH3:1][N:2]1[C:6]([OH:7])=[C:5]([C:8](=[O:17])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:4]([CH3:18])=[N:3]1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 178434070HCID 178434070, compound

Product 1

HCID 178457116HCID 178457116, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In 50 ml. of benzene is suspended 2.85 g. of 1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5-hydroxypyrazole and 0.7 g. of isopropylamine is added to the suspension with stirring. Then, the resulting mixture is stirred at room temperature for about 1 hour. The solvent is distilled off from the reaction mixture. The residue is cooled. The so separated solid material is recovered by filtration, washed with petroleum ether and dried to give 3.2 g. of the desired product as white powdery substance melting at 130°-140° C. Yield 93.2%.

Workup

  1. stirringThen, the resulting mixture is stirred at room temperature for about 1 hour
  2. distillationThe solvent is distilled off from the reaction mixture
  3. temperatureThe residue is cooled
  4. customThe so separated solid material
  5. filtrationis recovered by filtration
  6. washwashed with petroleum ether
  7. customdried
  8. customto give 3.2 g

Sources & evidence

ORD record
ord-ebbd9e90433b456dbcb13d438c60dd91
Source dataset
uspto-grants-1985_04
Patent number
US04508910

Reaction notes

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