HCID 20239875, compound → HCID 20402925, compound

HRID 1980401Notes

Reaction equation

HRID 1980401 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:26]=[CH:25][C:6]([C:7]([CH2:23][CH3:24])([OH:22])[C:8]2[CH:13]=[CH:12][C:11]([O:14]CC3C=CC=CC=3)=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[H][H]>[Pd].C1C=CC=CC=1>[F:1][C:2]([F:27])([F:28])[C:3]1[CH:26]=[CH:25][C:6]([C:7]([CH2:23][CH3:24])([OH:22])[C:8]2[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 20239875HCID 20239875, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20402925HCID 20402925, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 241BenzeneSolvent

Procedure

of 4-trifluoromethyl-4'-benzyloxy-α-ethyl-benzhydrol are dissolved in 270 ml. of benzene, and the solution is hydrogenated in the presence of 13.5 g. of a 10% palladium-on-charcoal catalyst. When the uptake of the calculated amount of hydrogen is complete (about 80 minutes), the catalyst is filtered off, benzene is distilled off under reduced pressure, and the residue is crystallized from a mixture of ethyl acetate and n-hexane. 19 g. of the named compound are obtained, melting at 126° to 127° C.

Workup

  1. custom(about 80 minutes)
  2. filtrationthe catalyst is filtered off
  3. distillationbenzene is distilled off under reduced pressure
  4. customthe residue is crystallized from a mixture of ethyl acetate and n-hexane
  5. customof the named compound are obtained

Sources & evidence

ORD record
ord-25938929b8b7424c97086eb1665f005c
Source dataset
uspto-grants-1985_04
Patent number
US04508926

Reaction notes

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