4-methoxypteridin-2-amine → HCID 13206549, compound

HRID 1980442Notes

Reaction equation

HRID 1980442 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH3:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=1.[F:14][C:15]1[CH:27]=[CH:26][CH:25]=[CH:24][C:16]=1[O:17][S:18]([N:21]=[C:22]=[O:23])(=[O:20])=[O:19]>C(Cl)Cl>[CH3:13][O:12][C:10]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=[C:2]([NH:1][C:22]([NH:21][S:18]([O:17][C:16]2[CH:24]=[CH:25][CH:26]=[CH:27][C:15]=2[F:14])(=[O:20])=[O:19])=[O:23])[N:11]=1

Participants

4

Reactant 2

HCID 2462834-methoxypteridin-2-amineHCID 204016482-Fluorophenyl sulfurisocyanatidate

Product 1

HCID 13206549HCID 13206549, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.88 g (0.005 mol) of 2-amino-4-methoxypteridine were suspended in 40 ml of methylene chloride and 1.2 g (0.0055 mol) of 2-fluorophenoxysulfonyl isocyanate were added thereto rapidly to obtain a clear solution. The solution was heated to reflux for a short time, thereafter stirred for 10 minutes and then was concentrated by evaporation to dryness. The residue was treated with diisopropyl ether and a little acetone and the mixture was vacuum filtered. The product was dried to obtain 1.95 of N-(4-methoxypteridin-2-yl)-N'-(2-fluorophenoxysulfonyl)-urea in the form of light yellow crystals melting at 135° C.

Workup

  1. customrapidly to obtain a clear solution
  2. temperatureThe solution was heated
  3. temperatureto reflux for a short time
  4. concentrationwas concentrated by evaporation to dryness
  5. additionThe residue was treated with diisopropyl ether
  6. filtrationfiltered
  7. customThe product was dried

Sources & evidence

ORD record
ord-360489c604374ff6abfca06680042914
Source dataset
uspto-grants-1985_04
Patent number
US04509972

Reaction notes

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