4-methoxypteridin-2-amine → N-(Aminocarbonyl)-2-(trifluoromethyl)benzenesulfonamide

HRID 1980443Notes

Reaction equation

HRID 1980443 reaction equation
NC1[N:11]=[C:10]([O:12]C)C2C(=NC=CN=2)N=1.[F:14][C:15]([F:29])([F:28])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([N:25]=C=O)(=[O:24])=[O:23]>C(Cl)Cl>[F:29][C:15]([F:14])([F:28])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([NH:25][C:10](=[O:12])[NH2:11])(=[O:24])=[O:23]

Participants

4

Reactant 2

HCID 2462834-methoxypteridin-2-amineHCID 11817579Benzenesulfonyl isocyanate, 2-(trifluoromethyl)-

Product 1

HCID 18472022N-(Aminocarbonyl)-2-(trifluoromethyl)benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.88 g (0.005 mol) of 2-amino-4-methoxypteridine and 1.30 g (0.0052 mol) of 2-trifluoromethylphenylsulfonyl isocyanate were reacted in 40 ml of methylene chloride according to Example 4 to obtain 2.0 g (94% of theory) of N-4-methoxypteridin-2-yl)-N'-(2-trifluoromethylphenylsulfonyl)-urea in the form of light yellow crystals melting at 187° C.

Sources & evidence

ORD record
ord-caa5d2066b764edf92741a224cde6cc6
Source dataset
uspto-grants-1985_04
Patent number
US04509972

Reaction notes

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