Benzenesulfonyl isocyanate, 2-chloro- → HCID 13206551, compound

Participants

Reaction Steps

1.5 g (0.0070 mol) of 2-chlorophenylsulfonyl isocyanate were added to a suspension of 1.3 g (0.0068 mol) of 2-amino-4-dimethylaminopteridine in 40 ml of acetonitrile and the mixture was stirred at reflux for 4 hours. The mixture was vacuum filtered and the filtrate was concentrated by evaporation. The residue was treated with acetone to obtain 2.05 g (74% of theory) of N-(4-dimethylaminopteridine-2-yl)-N'-(2-chlorophenylsulfonyl)-urea in the form of light yellow crystals melting at 232° C.

Provenance & Evidence