4-Methoxypteridin-2-amine → HCID 13235978, compound

Participants

Reaction Steps

To a suspension of 0.88 g (0.005 mol) of 2-amino-4-methoxypteridine in 40 ml of absolute methylene chloride were added with stirring to 1.35 g (0.053 mol) of 2,2,2-trichloroethoxysulfonyl isocyanate. After about 10 minutes, a clear solution had formed and it was heated to reflux. After 10 minutes, the mixture was evaporated to dryness and the residue was treated with diisopropyl ether and a little acetone. The mixture was vacuum filtered and the product was dried to obtain 2.05 g (95% of theory) of N-(4-methoxypteridin-2-yl)-N'-(2,2,2-trichloroethoxysulfonyl)-urea in the form of yellow crystals melting at 93° C. (decomp.).

Provenance & Evidence