HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-[2-(4-Methoxyphenylamino)benzoyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | N-(4-methoxyphenyl)isatoic anhydride | HCID 13505629 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[2-(4-Methoxyphenylamino)benzoyl]piperidine | HCID 13505630 | 85.5% |
Reaction Steps
A mixture of 15 g (0.052 mole) of N-(4-methoxyphenyl)isatoic anhydride and 10 ml (0.11 mole) of piperidine in 50 ml of dimethylformamide was stirred at room temperature for two hours. The reaction mixture was concentrated in vacuo and the residue recrystallized from 75 ml of isopropyl alcohol to give 13.8 g of 1-[2-(4-methoxyphenylamino)benzoyl]piperidine, colorless powder, m.p. 106°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04510139 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-24b67c77c0994040adbece10b835b56d |
| Source note | uspto-grants-1985_04 |