Sodium borohydride → HCID 13519279, compound

HRID 1980558Notes

Reaction equation

HRID 1980558 reaction equation
C[O:2][C:3]([C:5]1[N:24]=[C:8]2[CH2:9][N:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:11]3[N:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:7]2[N:6]=1)=O.[BH4-].[Na+]>>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[N:10]1[C:11]2[N:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:7]2[N:6]=[C:5]([CH2:3][OH:2])[N:24]=[C:8]2[CH2:9]1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 13519266HCID 13519266, compound

Product 1

HCID 13519279HCID 13519279, compound

Procedure

using 15.00 g (0.044 mol) of 5-(2-chlorophenyl)-4,5-dihydropyrido[2,3-e][1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid methyl ester and 8.28 g (0.219 mol) of sodium borohydride there is obtained 5-(2-chlorophenyl)-4,5-dihydropyrido[2,3-e][1,2,4]triazolo[1,5-a]pyrazine-2-methanol having a melting point of 193°-196°;

Sources & evidence

ORD record
ord-bf01ab4d365d4b1ab024103746552031
Source dataset
uspto-grants-1985_04
Patent number
US04510141

Reaction notes

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