反应详情

温度

150 °C

In a mixture of 18.1 ml of chlorosulfonic acid and 5.4 g of phosphorus pentachloride was gradually added 8.6 g of 4-piperidinoquinazoline, and the mixture was heated at 150° C. for 20 hours. The reaction solution was poured into 200 g of a mixture of ice and water and extracted with chloroform. The chloroform layer was washed with water, then with a saturated sodium bicarbonate solution, and dried with Glauber's salt. The chloroform layer thus obtained was condensed under reduced pressure to give 6.0 g of 4-piperidino-6-quinazolinesulfonyl chloride as an oily substance.

1. extractionextracted with chloroform
2. washThe chloroform layer was washed with water
3. dry with materialwith a saturated sodium bicarbonate solution, and dried with Glauber's salt
4. customThe chloroform layer thus obtained
5. customcondensed under reduced pressure