Hexamethyldisilazane → Lithium Hexamethyldisilazide

Participants

Reaction Steps

A solution of lithium hexamethyldisilazide was prepared by the addition of 3.53 ml of a 1.6M solution of n-butyllithium in hexane to 1.19 ml of hexamethyldisilazane in 25 ml of dry tetrahydrofuran at -10° with stirring under argon. The solution was cooled to -78° and added by cannula to 1.02 g of pivaloyloxymethyl 2-(4-allylthioazetidin-2-on-1-yl) acetate in 10 ml of dry tetrahydrofuran at -78° with stirring under argon.

Provenance & Evidence