3-Amino-1,2-propanediol → 2-[4-[2-[[4-(2,3-dihydroxypropylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl]amino]ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine

Participants

Reaction Steps

When a methanolic solution of 2-[(2-guanidinothiazol-4-yl)methylthio]ethylamine is reacted with 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide by the procedure of Example 31 and the resultant 3-methoxy-4-{2-[(2-guanidinothiazol-4-yl)methylthio]ethylamino}-1,2,5-thiadazole 1,1-dioxide is treated with 3-amino-1,2-propanediol, the title compound is thereby produced.

Provenance & Evidence