Ammonia → 3-Amino-4-{2-[(2-dimethylaminomethyl-4-thiazolyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide

HRID 1980692Notes

Reaction equation

HRID 1980692 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[C:19](OC)=[N:18][S:17](=[O:22])[N:16]=2)[N:9]=1)[CH3:3].COC1C(OC)=NS(=O)[N:26]=1.N>>[NH2:26][C:19]1[C:15]([NH:14][CH2:13][CH2:12][S:11][CH2:10][C:8]2[N:9]=[C:5]([CH2:4][N:2]([CH3:3])[CH3:1])[S:6][CH:7]=2)=[N:16][S:17](=[O:22])[N:18]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 129139473,4-Dimethoxy-1,2,5-thiadiazole 1-oxideHCID 204021103-{2-[(2-Dimethylaminomethyl-4-thiazolyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1-oxide

Product 1

HCID 159612343-Amino-4-{2-[(2-dimethylaminomethyl-4-thiazolyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide

Procedure

When a methanolic solution of 3-{2-[(2-dimethylaminomethyl-4-thiazolyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1-oxide [prepared from 3,4-dimethoxy-1,2,5-thiadiazole 1-oxide by the general procedure described in Example 34, Step F] is reacted with anhydrous ammonia according to the general procedure described in Example 35, the title compound is thereby produced.

Sources & evidence

ORD record
ord-e35045d74611472fb5cce56c5f27d35a
Source dataset
uspto-grants-1985_04
Patent number
US04510309

Reaction notes

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