3-Pyridinemethanamine → 3-Methoxy-4-(3-pyridyl)methylamino-1,2,5-thiadiazole 1-oxide

HRID 1980747Notes

Reaction equation

HRID 1980747 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[CH3:9][O:10][C:11]1[C:15](OC)=[N:14][S:13](=[O:18])[N:12]=1>CO>[CH3:9][O:10][C:11]1[C:15]([NH:1][CH2:2][C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)=[N:14][S:13](=[O:18])[N:12]=1

Participants

4

Reactant 2

HCID 310183-PyridinemethanamineHCID 129139473,4-Dimethoxy-1,2,5-thiadiazole 1-oxide

Product 1

HCID 204020453-Methoxy-4-(3-pyridyl)methylamino-1,2,5-thiadiazole 1-oxide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

A solution of 3-aminomethylpyridine (2.02 g; 18.7 mmoles) in 80 ml of methanol was added dropwise over 40 minutes to a partial suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1-oxide (3.03 g; 18.7 mmoles) in 150 ml of methanol, to produce a methanol solution of the title compound.

Sources & evidence

ORD record
ord-fbee0509122546a895eafdc1bc910103
Source dataset
uspto-grants-1985_04
Patent number
US04510309

Reaction notes

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