反应详情

To the methanol solution of 3-methoxy-4-(3-pyridyl)methylamino-1,2,5-thiadiazole 1-oxide produced in Step A was added a solution of 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine (4.0 g; 18.7 mmoles) in 30 ml of methanol. The reaction mixture was stirred at ambient temperatures for 18 hours and the solvent was removed in vacuo. The residue was placed on 500 g of silica gel (230-400 mesh) and purified by flash chromatography using a gradient elution of acetonitrile-methanol After combining the appropriate fractions, the title compound was obtained as an amber oil (4.25 g) containing one mole of methanol.

1. customthe solvent was removed in vacuo
2. custompurified by flash chromatography
3. washa gradient elution of acetonitrile-methanol